Methylation and breast cancer

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Impact factor 8. Nanotheranostics - Submit manuscript now International Journal of Biological Sciences.

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Data generated or analyzed during this study is included in this article and its supplementary tables. Immune surveillance acts as a defense mechanism in cancer, and its disruption is involved in cancer progression. DNA methylation reflects the phenotypic identity of cells and recent data suggested that DNA methylation profiles of T cells and peripheral blood mononuclear cells PBMC are altered in cancer progression.

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Imagine being able to detect the beginning stages of cancer up to a year earlier than current methodologies allow. Importantly, these patterns are present in blood serum before cancer becomes detectable in the breast. The addition of methyl groups to DNA is a cellular mechanism that has evolved to regulate gene expression, and aberrant DNA methylation has been shown to be common in human tumors —specifically during the preliminary stages of breast cancer development.

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Biomarkers of DNA methylation, which regulate gene expression, can be a predictor of breast cancer risk, according to a study published in Journal of the National Cancer Institute. Vanderbilt's Jirong Long, Ph. They discovered DNA methylation sites associated with breast cancer, including 45 sites located in novel chromosome regions that had not been previously reported for breast cancer. Integrative analyses of genetic DNA methylation and gene expression data found that 38CpGs may affect breast cancer risk through regulating expression of 21 genes.

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China Date of Web Publication Jun Aim of Study: The current meta-analysis investigated the correlation between breast cancer type 1 BRCA1 promoter methylation and the clinicopathological features of breast cancer BC. Materials and Methods: An electronic literature search was performed to identify and select cohort studies, by employing stringent inclusion and exclusion criteria, for data relevant to promoter methylation of BRCA1 and BC.

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DNA methylation has been implicated in breast cancer aetiology, but little is known about whether reproductive history and DNA methylation interact to influence carcinogenesis. This study examined modification of the association between global DNA methylation and breast cancer risk by reproductive characteristics. A population-based case-control study assessed reproductive history in an interviewer-administered questionnaire.

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Peripheral blood DNA methylation may be associated with breast cancer, but studies of candidate genes and global and genome-wide DNA methylation have been inconsistent. The correlation between methylation and time to diagnosis was examined using robust linear regression. All statistical tests were two-sided.

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Author s : A. FergusonS. DOI : Traditionally, scientists have focused on structural changes in DNA sequences, such as mutations and deletions, as the cause for altered patterns of gene expression in human cancer.

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Breast cancer is a highly heterogeneous disease resulting in diverse clinical behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that is commonly perturbed in cancers. The aim of this study is to characterize the relationship between DNA methylation and aberrant gene expression in breast cancer.

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