Estrogen receptor alpha breast cancer

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Journal of Mammary Gland Biology and Neoplasia. Estrogens have long been recognized as being important for stimulating the growth of a large proportion of breast cancers. Unable to display preview.

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Core tip: The inhibition of the estrogen receptor alpha polyubiquitination and degradation by several molecular mechanisms is related to the progression of breast cancer and resistance to endocrine therapy. Moreover, transcriptional coregulators are recruited by the AF-1 and AF-2 domains of the receptor for the remodeling of the chromatin structure[ 910 ] and promotion of chromatin loops that modulate E2-responsive gene expression[ 1112 ]. Here, we describe these evidences.

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Describe the role of epigenetic information in the regulation of gene expression and in the development of cancer. Explain the important role of estrogen receptor expression in breast cancer as a prognostic marker and predictive factor of response to endocrine therapy. Evaluate the current and potential role that the comprehension of the molecular biology of a tumor may have in finding a new therapeutic approach in cancer treatment.

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Cells react to a variety of stresses, including accumulation of unfolded or misfolded protein, by activating the endoplasmic reticulum EnR stress sensor, the unfolded protein response UPR. The UPR is highly conserved and plays a key role in the maintenance of protein folding quality control and homeostasis. In contrast to the classical reactive mode of UPR activation, recent studies describe a hormone-activated anticipatory UPR.

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Citation: Rajeev Kumar, et al. J Cancer Res Therap Oncol 2: Abstract Full Text References Tables and Figures Abstract Breast cancer BCa is a common endocrine disorder among postmenopausal women and estradiol E2 known causative agent for metastasis.

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We previously performed an siRNA screening 20 and identified kinases whose silencing alters the genomic E 2 response. LATS2 also regulates p53 via interactions with murine double minute-2 MDM2 39 and has been reported to be a negative regulator of the androgen receptor Interestingly, LATS2 is down-regulated in many types of cancers including leukaemia 42astrocytoma 43prostate cancer 40 and breast cancer

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Bio GRID 3. Publication Search Go. Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells. The effects of estrogen and anti-estrogen are mediated through the estrogen receptors ER alpha and beta, which function as ligand-induced transcriptional factors.

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This is an open access article distributed under the terms of the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability: All relevant data are within the paper and its Supporting Information files. Mand 5F31CA to L.

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